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Pathological anatomy and cytology

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This medical speciality, positioned at a crossroad between the clinical, surgical, imaging, biological and research fields, plays a key role in the diagnosis, prognosis and treatment of benign or malignant diseases.

The PAC test is based on the morphological analysis of cells and tissues under the microscope, which is essential for the diagnosis and management of cancers. Another important aspect of this activity is the screening of precancerous lesions based on epidemiological structures.

All medical specialities require PAC, and the Eurofins Biomnis PAC laboratory illustrates this versatility through active collaborations in urology, hepato-gastroenterology, and gynaecology services, as well as other areas such as dermatology, pneumology, oropharyngeal cancers, endocrinology… In the area of tumour pathology, the PAC physicians can sometimes provide a preoperative or extemporaneous diagnosis, and take part in the examination of a file during multidisciplinary meetings. Our laboratory is particularly skilled and recognised for its expertise in gynaecological cytology and hepatic pathology.

The PAC uses various conventional techniques (histology, immunohistochemistry, cytology, corresponding to “morphological pathology”), as well as molecular biology and cytogenetics techniques, which are essential to clarify the diagnosis and/or prognosis of certain cancers. The PAC laboratory works closely with virologists on the genotyping of the HPV virus, and with the Research Unit of the Biology of Haematological Malignancies and Cancers (Unité de Biologie des Hémopathies Malignes et des Cancers) using complementary techniques designed primarily for breast cancers (c-erb-2 status) and gastrointestinal cancers (K-ras), and for the identification of sarcomas (gene rearrangement).

In the area of cytology, the PAC laboratory offers a vast expertise in the liquid-based technique and is equipped with image analyzers for the computed-assisted reading of gynaecological smears.


Pathological anatomy and cytology

Focus 52HPV infection in 2014
Focus on – Human papillomavirus and cervical cancer screening
Focus on – KRAS mutation status