Fertility Testing and Embryology
With over 20 years experience Eurofins Biomnis can provide you with direct access to an extensive list of blood tests that will help your doctor medically assess the factors that may be affecting your ability to conceive.
Patients wishing to avail of our medical testing service are required to provide the relevant blood sample to us for analysis. Please note that we do not offer a phlebotomy service to draw. However there are facilities nearby that do provide this service and details will be provided upon request. Alternatively please contact your GP or healthcare provider who may also be able to provide you with this service.
Listed below is a selection of the common tests required by your healthcare professional:
- Follicle Stimulating Hormone (FSH): This test will measure the levels of FSH being produced by your body. FSH triggers the follicles within your ovaries to begin preparing for the release of an egg. High levels of FSH are generally an indicator that egg reserves are running low.
- Luteinizing hormone (LH): lutenizing hormone controls egg development. LH helps regulate the menstrual cycle and egg production (ovulation). The level of LH in a woman's body varies with the phase of the menstrual cycle. It increases rapidly just before ovulation occurs, about midway through the cycle (day 14 of a 28-day cycle). This is called an LH surge. Consistently high levels of this hormone in your body can prevent this release, and might also be an indicator of Polycystic Ovary Syndrome.
- Prolactin: This blood test will measure levels of prolactin. Prolactin is a stress hormone that is released by the pituitary gland. High levels of prolactin can prevent the release of FSH and LH. Both of these hormones are responsible for helping your eggs to develop and mature in the ovaries, so that they can be released during ovulation. When you have excess prolactin in your bloodstream, ovulation is not triggered. Prolactin is the hormone that also eventually stimulates the production of breast milk.
- Anti Mullerian Hormone (AMH): AMH is produced by ovarian follicles containing eggs. The levels of AMH found in the blood is an indicator of a woman's ovarian reserve. As the level of Anti-Müllerian hormone found in the blood does not fluctuate throughout the month, it is the most reliable single predictor of whether a woman is still fertile and how many eggs she has left in her ovaries.
- Progesterone: Progesterone is a hormone produced mainly in the ovaries. Progesterone levels rise following ovulation, peaking five to nine days after ovulation. This is known as your luteal phase. This test is usually performed on day 21 of your menstrual cycle to determine if ovulation has taken place.
- Thyroid Stimulating Hormone: TSH levels are usually tested to check for thyroid disease, which is common among women. Abnormal thyroid function may cause fertility problems.
- Estradiol: This hormone is produced by follicles in the ovaries. An elevated E2 level on the third day of your cycle could indicate a compromised ovarian reserve despite a normal FSH level.
- Sex Hormone Binding Globulin, testosterone and the free androgen index: In women, small amounts of testosterone are produced by the ovaries and adrenal glands. Even slight increases in testosterone production can disrupt the balance of hormones and cause infertility.
Eurofins Biomnis has a particularly well-developed sperm diagnostics unit which can perform the complete range of examinations: sperm count, sperm quality, sperm culture, tests of sperm migration and survival, semen biochemistry, investigation for antisperm antibodies (in seminal fluid but also possibly in the blood of the man or woman, and in cervical mucus), and tests focussing on nucleus quality: analysis of the DNA fragmentation index (DFI) for sperm and the sperm DNA decondensation test using flow cytometry (SCSA® technique), ultrastructural examination of the head of motile sperm (MSOME or pre-IMSI test), and caryotyping by in situ hybridisation (FISH).
Some of these examinations can even be sent to us from a laboratory near you (sperm quality analysis, sperm DNA fragmentation index, antisperm antibodies, semen biochemistry, FISH).
After the diagnosis, we can work in close collaboration with a team of qualified gynaecologists to perform all techniques:
- preparation of sperm for intrauterine insemination (IUI),
- conventional in vitro fertilisation (IVF),
- IVF with micromanipulation (ICSI) or after in-depth analysis of the sperm (IMSI).
In some special cases, the sperm may be removed surgically (epididymal sperm and/or testicular biopsy).
Eurofins Biomnis has also developed expertise in the freezing of gametes and embryos:
- vitrification of oocytes and embryos,
- cryopreservation, and elective sperm freezing.
Our laboratories will offer you a method of embryo transfer personalised to each couple: transfer of fresh or thawed embryos at the stage of early embryo cleavage or at the blastocyst stage.
Throughout your journey with our assisted reproductive technology (ART) centres, you will be supported and advised by medical pathologists specialising in reproduction. You will be able to meet with them to develop together the most suitable strategy for your couple and your individual situation.
In this evolving field, Eurofins Biomnis is participating in many collaborative clinical and biological research studies, both at national and international level. Eurofins Biomnis is involved in many aspects of couple infertility, in particular assessment of the effects of oxidative stress on gametes, embryo culture in a closed system with TIME-LAPSE technology, and assessment of endometrial receptivity using marker genes.