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Endocrinology

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Endocrinology

Hormone assays are essential for the diagnosis and therapeutic follow-up of pathologies resulting from endocrine dysfunction.

More than 60 parameters are routinely measured in serum, plasma or saliva, and metabolites can be assayed in urine, including steroids (androgens, oestrogens, glucocorticoids, mineralocorticoids), peptides (ACTH, ADH, C-Peptide) and proteins (gonadotropin, prolactin, TSH, GH, HCG, insulin) for the investigation of the function of all endocrine glands, including the thyroid, the gonads, the pituitary gland, the adrenal cortex, the pancreas and the placenta. Other tests investigate glucose metabolism and growth. These investigation also extend to the determination of auto-antibodies (against the thyroid, insulin, GAD-65, IA2, etc.) and transport proteins (Testosterone-Oestradiol Binding Globulin, IGF-BP3, IGF-BP1).

These assays can help with the diagnosis and therapeutic monitoring of diseases that are caused by impaired endocrine function, e.g. male and female infertility, premature and delayed puberty, hypogonadism, growth disorders, female hyperandrogenism and hirsutism, high blood pressure, dysthyroidism and diabetes.

Biomnis performs these assays using techniques compliant with the different analytical requirements, which occasionally include radioimmunology.

On the other hand, LC/MS-MS is used to assay simultaneously catecholamines and their methylated derivatives in urine and plasma. Owing to its high performance, in terms of sensitivity and specificity, this assay can detect free forms of plasma methoxyamines, with greater specificity, especially for the diagnosis of pheochromocytoma.

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