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Autoimmunity

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Autoimmune diseases affect 5-7% of the world’s population, representing the third most common cause of morbidity in developed countries (after cardiovascular disease and cancer). Virtually any molecule in the body may act as an auto-antigen and induce an autoimmune reaction, meaning that the range of detectable auto-antibodies is very wide. Auto-antigens may be expressed in cells and distributed throughout the body (non-organ-specific diseases) or in only in a specific part of a given organ. In some pathological situations, auto-antibodies are extremely sensitive markers which can be detected months or even years before the onset of symptoms.

An autoimmune reaction may develop against many autoantigens present in our body, which accounts for the diversity of autoantibodies available for research. The different types of Auto Immune Disease (AID) fall into two main categories: organ non-specific and organ-specific. The non-specific AID are generally connective tissue diseases and they are associated with a wide variety of clinical symptoms. The organ-specific AID target the antigens of a single organ.

Eurofins Biomnis can detect over 100 different autoantibodies, including rare or newly discovered types found in myositis, neurological diseases, blistering skin diseases.

Our laboratory uses several techniques to assist in the biological diagnosis of AID: indirect immunofluorescence, the Luminex technology on the Bio-Plex platform, immunoassays, immunoblots. The results are provided on Day 1 for the most common parameters and in less than a week for most of the rare autoantibodies.

 

Resources

Autoimmunity

Focus 45Coeliac Disease
Focus 40Anti-DNA antibodies
Focus 31Autoimmune Hepatitis
Focus 29ANCA
Focus 28Anti-nuclear antibodies
Focus 26ACC
Focus 16New coeliac disease
Focus 12Auto-immune intestinal diseases
Focus 7Bullous Dermatosis
Focus on – Auto immune disease