Multiple pathologies are diagnosed and monitored using protein studies: monoclonal gammopathies, inflammatory syndromes, immune deficiencies, kidney diseases, multiple sclerosis, etc.
The screening, identification, and follow-up of monoclonal dysglobulinemia (gammopathies involving Ig G, A, M, D, E and the kappa/lambda free light chains) are performed by capillary electrophoresis, immunoelectrophoresis or immunofixation of serum and urinary proteins. Urinary proteins are also analysed, with or without dilutions, using high-resolution agarose electrophoresis and immunofixation. Specific assays are performed for serum and urinary proteins by immunonephelometry and immunoturbidimetry, especially for immunoglobulins and the kappa/lambda free light chains.
The proteins of the cerebrospinal fluid are analysed using the reference method of isoelectric focussing, which generates a profile of IgG oligoclonal bands (OCBs). Eurofins Biomnis collaborates with the CNR (Centre National de Référence; National Reference Center) for the diagnosis of heavy chain diseases.